Exercise 9: how NOT to report a CRM trial

In this exercise, we will first do a critical reading of the article from Kaguelidou et al. (2016) ¹.

1. List the method elements that are missing from this article.

2. Read and discuss Table 3.

3. Load the R package bcrm and conduct an imaginary CRM trial interactive with the following code lines:

   library(bcrm)
   sdose <- c(1, 1.5, 2, 2.5, 3)
   dose.label <- c(5, 10, 15, 25, 40, 50, 60)
   p.tox0 <- c(0.01, 0.015, 0.02, 0.025, 0.03, 0.04, 0.05)
   bcrm(stop = list(nmax = 42), p.tox0 = p.tox0, dose = dose.label, ff = "power", prior.alpha = list(1,
       1, 1), target.tox = 0.3, start = 1)